Modulation of the NOtranseffect in heme proteins: implications for the activation of soluble guanylate cyclase
✍ Scribed by Marcelo A. Martí; Damián A. Scherlis; Fabio A. Doctorovich; Pablo Ordejón; Darío A. Estrin
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 389 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1432-1327
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## Background: Nitric oxide (.no) is used in biology as both an intercellular signaling agent and a cytotoxic agent. in signaling, submicromolar quantities of .no stimulate the soluble isoform of guanylate cyclase (sgc) in the receptor cell. .no increases the vmax of this heterodimeric hemoprotein
## Abstract Guanylate cyclase activating protein‐2 (GCAP‐2) is a Ca^2+^‐binding protein of the neuronal calcium sensor (NCS) family. Ca^2+^‐free GCAP‐2 activates the retinal rod outer segment guanylate cyclases ROS‐GC1 and 2. Native GCAP‐2 is N‐terminally myristoylated. Detailed structural informat