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Modulation of the motor response to dopaminergic drugs in a parkinsonian model of combined dopaminergic and noradrenergic degeneration

✍ Scribed by Virgili Pérez; Victoria Sosti; Antonia Rubio; Manel Barbanoj; José Rodríguez-Álvarez; Jaime Kulisevsky

Book ID: 113587155
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 240 KB
Volume: 576
Category: Article
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2007.08.024

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## Abstract We have performed proteomic analysis in the cerebrospinal fluid in an animal model of Parkinson's disease induced by axotomy of the medial forebrain bundle. In this model, the degeneration of dopaminergic neurons was completed in 14 days, with a loss of about 50% dopaminergic neurons in