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Modulation of the Membrane Orientation and Secondary Structure of the C-Terminal Domains of Bak and Bcl-2 by Lipids †

✍ Scribed by Torrecillas, Alejandro; Martínez-Senac, María M.; Goormaghtigh, Erik; de Godos, Ana; Corbalán-García, Senena; Gómez-Fernández, Juan C.


Book ID
126029337
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
221 KB
Volume
44
Category
Article
ISSN
0006-2960

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✍ Lucie Khemtémourian; Marc-Antoine Sani; Katell Bathany; Gerhard Gröbner; Erick J 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 294 KB

## Abstract Solid phase synthesis of BH4, the 26 amino‐acid domain (^6^RTGYDNREIVMKYIHYKLSQRGYEWD^31^) of the anti‐apoptotic Bcl‐2 protein has been accomplished using Fmoc chemistry. The use of peculiar cleavage conditions provided high yields after purification such that tens to hundreds of mg cou