In this study, we investigated the effect of the extracellular matrix (ECM) secreted by vascular cells on proteoglycan (PG) synthesis by vascular smooth muscle cells in culture. PG synthesis of human aortic smooth muscle cells plated on plastic or the matrices derived from vascular endothelial cells
Modulation of sulfated glycosaminoglycan and small proteoglycan synthesis by the extracellular matrix
✍ Scribed by Yanusz Wegrowski; Philippe Gillery; Grazyna Kotlarz; Corrine Perreau; Nadine Georges; François-Xavier Maquart
- Book ID
- 110247264
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 141 KB
- Volume
- 205
- Category
- Article
- ISSN
- 0300-8177
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## Abstract Exposure of endothelial cells to heparin and other antithrombotic drugs specifically stimulates the synthesis of an antithrombotic heparan sulfate (HS). In the present work, biotinylated heparin (BiotHep) was used to characterize the binding site(s) of heparin responsible for the stimul