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Modulation of substrate specificity of the DnaK chaperone by alteration of a hydrophobic arch

✍ Scribed by Stefan Rüdiger; Matthias P Mayer; Jens Schneider-Mergener; Bernd Bukau

Book ID
115630623
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
368 KB
Volume
304
Category
Article
ISSN
0022-2836

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✍ Regina S. Schweizer; Dr. Raphael A. Aponte; Sabine Zimmermann; Annika Weber; Dr. 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 659 KB

## Abstract DnaK is a member of the Hsp70 family of molecular chaperones. This molecular machine couples the binding and hydrolysis of ATP to binding and release of substrate proteins. The switches that are involved in allosteric communication within this multidomain protein are mostly unknown. Pre