Modulation of RNA function by aminoglycoside antibiotics
โ Scribed by Schroeder, R.
- Book ID
- 115472264
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 927 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0261-4189
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๐ SIMILAR VOLUMES
## Abstract The increased awareness of the central role of RNA has led to realization that RNA, as structural and functional information accumulation, is also drug target to small molecular therapy. Aminoglycosides are a group of wellโknown antibiotics, which function through binding to specific si
Electrospray ionization mass spectrometry (ESI-MS) has been used to determine the dissociation constants (K(D)s) and binding stoichiometry for tobramycin and paromomycin with a 27-nucleotide RNA construct representing the A-site of the 16S ribosomal RNA. K(D) values determined by holding the ligand