Modulation of prion protein structure by pressure and temperature
β Scribed by Joan Torrent; Maria Teresa Alvarez-Martinez; Jean-Pierre Liautard; Reinhard Lange
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 241 KB
- Volume
- 1764
- Category
- Article
- ISSN
- 1570-9639
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## Raman spectroscopy, X-ray and electron diffractions have been applied to study samples of fullerene C,, after they have undergone pressure and temperature treatments up to 8 GPa and 1073 K. It is confirmed that mixtures of rhombohedral and tetragonal structures are formed in the 2-4 GPa and 673
A synthetic peptide consisting of amino acid residues 106 to 126 of the human prion protein (PrP c ) that forms fibrils in vitro is toxic to cultured neurons. We have previously shown that the neurotoxic effect of this peptide is related to microglia activation (Brown et al., 1996a). For closer insi