Modulation of platelet aggregation responses by leukocytapheresis therapy in patients with active ulcerative colitis
β Scribed by Yuhki Yagi; Akira Andoh; Osamu Inatomi; Shigeki Bamba; Tomoyuki Tsujikawa; Yoshihide Fujiyama; Keiichi Mitsuyama; Takashi Yoshida
- Book ID
- 106179921
- Publisher
- Springer Japan
- Year
- 2006
- Tongue
- English
- Weight
- 251 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0944-1174
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π SIMILAR VOLUMES
## Abstract **Background**: Leukocytapheresis (LCAP) is used as an adjunct therapy for patients with active ulcerative colitis (UC). Although, LCAP is routinely performed at 3,000 mL per session, we were interested to see that if this can be replaced with bodyweight (BW) adjusted volume. **Methods*
Background: During active ulcerative colitis (UC), vast numbers of granulocytes, monocytes/macrophages (GM) infiltrate the mucosal tissue and can potentially exacerbate inflammation and injury. Accordingly, we were interested to see if selective depletion of GM by adsorption (GMA) impacts mucosal he