MODULATION OF PITUITARY RESPONSIVENESS TO EXOGENOUS LHRH BY AN OESTROGENIC AND AN ANTI-OESTROGENIC COMPOUND IN THE NORMAL MALE

The peripubertal male rat assay as an al

The peripubertal male rat assay as an alternative to the Hershberger castrated male rat assay for the detection of anti-androgens, oestrogens and metabolic modulators

✍ J. Ashby; P. A. Lefevre 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB

A range of chemicals with various levels of activity as actual or potential endocrine disrupters have been evaluated for activity in the peripubertal male rat assay. The chemicals studied included anti-androgens (vinclozolin), cyproterone acetate, flutamide, 2, 2-bis(4-chlorophenyl)-1,1-dichloroethy