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Modulation of p53 after maternal exposure to all-trans-retinoic acid in Swiss Webster mouse fetuses

✍ Scribed by Suparna A Sarkar; Raghubir P Sharma


Book ID
114018086
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
668 KB
Volume
74
Category
Article
ISSN
0014-4800

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Acute promyelocytic leukemia (APL) is highly malignant and frequently expresses the PML-RAR␣ (promyelocytic leukemia-retinoic acid receptor-␣) fusion protein. This fusion protein is targeted by all-trans retinoic acid (ATRA) and arsenic trioxide (As 2 O 3 ), presently used in APL therapy. We have ev