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Modulation of P-glycoprotein-mediated multidrug resistance in K562 leukemic cells by indole-3-carbinol

✍ Scribed by Annu Arora; Kavita Seth; Neetu Kalra; Yogeshwer Shukla

Book ID: 113923407
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 324 KB
Volume: 202
Category: Article
ISSN: 0041-008X
DOI: 10.1016/j.taap.2004.06.017

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## Abstract P‐glycoprotein (P‐gp) is a plasma membrane glycoprotein that has been signaled as a primary cause of multidrug resistance (MDR) in tumors. We performed a yeast 2‐hybrid screen using the C‐terminal domain of P‐gp and identified 2 small GTPases involved in vesicular trafficking, Rab4 and