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Modulation of oncogene and tumor suppressor gene expression for prevention and therapy of lung cancer

Book ID
122883189
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
285 KB
Volume
10
Category
Article
ISSN
0169-5002

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Epigenetic modulation of endogenous tumo
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โœ Joshua P. Cantor; Dimitrios Iliopoulos; Atul S. Rao; Teresa Druck; Shuho Semba; ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 545 KB

## Abstract Epigenetic changes involved in cancer development, unlike genetic changes, are reversible. DNA methyltransferase and histone deacetylase inhibitors show antiproliferative effects __in vitro__, through tumor suppressor reactivation and induction of apoptosis. Such inhibitors have shown a