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Modulation of mitomycin C-induced multidrug resistance in vitro

✍ Scribed by Robert T. Dorr; James D. Liddil


Publisher
Springer
Year
1991
Tongue
English
Weight
547 KB
Volume
27
Category
Article
ISSN
0344-5704

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In a P-glycoprotein-negative cell line, GLC,-Adr,, a 75-fold acquired Adriamycin (Adr) resistance coincided with a reduced cellular Adr level, an increased detoxifying capacity (glu- tathione (GSH) and glutathione S-transferase (GST) elevated), and a reduced topoisomerase-ll (topo-11) activity compa