Combined in vitro modulation of adriamyc
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C. Meijer; N. H. Mulder; H. Timmer-Bosscha; W. H. M. Petfrs; E. G. E. de Vries
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Article
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1991
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John Wiley and Sons
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French
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In a P-glycoprotein-negative cell line, GLC,-Adr,, a 75-fold acquired Adriamycin (Adr) resistance coincided with a reduced cellular Adr level, an increased detoxifying capacity (glu- tathione (GSH) and glutathione S-transferase (GST) elevated), and a reduced topoisomerase-ll (topo-11) activity compa