## Abstract Bexarotene has demonstrated chemopreventive and therapeutic efficacy towards mouse lung tumors. Using specimens from our published study that demonstrated the efficacy of bexarotene, we report herein its ability to modulate mRNA expression of genes in both lung and lung tumors. Strain A
Modulation of microrna expression by volatile organic compounds in mouse lung
β Scribed by Fan Wang; Chonglei Li; Wei Liu; Yihe Jin
- Book ID
- 112221837
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 585 KB
- Volume
- 29
- Category
- Article
- ISSN
- 1520-4081
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## Abstract Biomarkers are being developed that can aid in the evaluation of cancer therapeutic and chemopreventive drugs. Two suggested biomarkers found in mouse lung tumors are DNA hypomethylation and alterations in mRNA expression of genes, such as 18S RNA, caspase 3, cyclin B2, cyclin E1, iNOS
## Abstract ## BACKGROUND. The specific volatile organic compounds (VOCs) exhaled by lung cancer cells in the microenvironment are the source biomarkers of lung cancer and also serve as direct evidence that the diagnosis of lung cancer by breath is possible. However, to the authors' knowledge, few