We investigated the regulatory mechanism of interleukin-6 (IL-6) synthesis induced by interleukin-1 (IL-1) in osteoblast-like MC3T3-E1 cells. IL-1 stimulated the secretion of IL-6 in a dose-dependent manner in the range between 0.1 and 100 ng/ml. Staurosporine and calphostin C, inhibitors of protein
✦ LIBER ✦
Modulation of lipopolysaccharide-induced NF-IL6 activation by protein kinase C-α in a mouse macrophage cell line
✍ Scribed by Frédéric Chano; Albert Descoteaux
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 190 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0014-2980
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## Abstract Modulation of the Ca^2+^ sensitivity and cooperativity of secretion is an important means of regulating neurotransmission and hormone secretion. Employing high‐time resolution measurement of membrane capacitance (Cm) stimulated by step‐like or ramp [Ca^2+^]~i~ elevation, we have identif