Modulation of Kir4.1 and Kir5.1 by hypercapnia and intracellular acidosis
β Scribed by Haoxing Xu; Ningren Cui; Zhenjiang Yang; Zhiqiang Qu; Chun Jiang
- Book ID
- 111119219
- Publisher
- Cambridge University Press
- Year
- 2000
- Tongue
- English
- Weight
- 249 KB
- Volume
- 524
- Category
- Article
- ISSN
- 0022-3751
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## Abstract Several inward rectifier K^+^ (Kir) channels are pHβsensitive, making them potential candidates for CO~2~ chemoreception in cells. However, there is no evidence showing that Kir channels change their activity at near physiological level of P, as most previous studies were done using hig
## Abstract The heteromeric Kir4.1βKir5.1 channel is a candidate sensing molecule for central CO~2~ chemoreception. Since central CO~2~ chemoreception is subject to neural modulations, we performed studies to test the hypothesis that the Kir4.1βKir5.1 channel is modulated by the neurotransmitters c