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Modulation of K+-channels in p-neurones of the leech CNS by phosphorylation

✍ Scribed by M. Goldermann; W. Hanke; W. R. Schlue

Publisher
Springer
Year
1994
Tongue
English
Weight
463 KB
Volume
174
Category
Article
ISSN
0340-7594

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✦ Synopsis

Two types of potassium channels of identified (p-) neurones of the leech (Hirudo medicinalis) were investigated by using the patch-clamp technique. The openstate probability of these channels in cell-attached patches can be reduced by addition of 5-hydroxytryptamine to the bath solution. After excising the patches the application of alkaline phosphatase to the cytosolic face of the patch increases the open probability. The 5-HT1A-receptor agonist buspirone mimics the effect of 5-HT. Our experiments show that the effect of 5-HT might be due to a channel phosphorylation via a 5-HT1A-receptor subtype.

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