𝔖 Bobbio Scriptorium
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Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells

✍ Scribed by Silvia Peñuelas; Véronique Noé; Carlos J. Ciudad


Book ID
111309832
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
840 KB
Volume
272
Category
Article
ISSN
1432-1327

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## Abstract Multidrug resistant (MDR) tumor cells exhibit an altered pH gradient across different cell compartments, which favors a reduced intracellular accumulation of antineoplastic drugs and a decreased therapeutic effect. In our study, we have observed that the activity and expression of Na^+^