Modulation of hypoxia-inducible factors (HIF) from an integrative pharmacological perspective
✍ Scribed by Francisco Javier Rodríguez-Jiménez; Victoria Moreno-Manzano
- Book ID
- 105759586
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 433 KB
- Volume
- 69
- Category
- Article
- ISSN
- 1420-682X
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## Abstract At the cellular level hypoxia induces transcriptional response that is mediated by the transcription factor hypoxia‐inducible factor (HIF). HIF is regulated at the level of its α subunit by 2‐oxoglutarate (2OG)‐dependent oxygenases that hydroxylate specific prolyl and asparaginyl residu
## Abstract The hypoxia‐inducible factors (HIFs) are dimeric transcription factors that mediate changes in gene expression during adaptation of animals to oxygen stress. Both alpha (HIFα) and beta (ARNT) subunits are members of the basic helix‐loop‐helix/Per‐ARNT‐Sim family of proteins. Mammals hav