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Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids

✍ Scribed by Pornngarm Limtrakul; Songyot Anuchapreeda; Duang Buddhasukh

Book ID
115010539
Publisher
BioMed Central
Year
2004
Tongue
English
Weight
552 KB
Volume
4
Category
Article
ISSN
1471-2407

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The most consistantly reported alteration of multidrug-resistant carcinoma cells is the overexpression of a membrane glycoprotein, termed P-glycoprotein. In this study we examined whether the strong intrinsic chemotherapy resistance of glial tumors might be related to the expression of the MDR1 gene