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Modulation of glioma cell invasion and motility by adenoviral gene transfer of PAI-1

✍ Scribed by G.O. Hjortland; K. Bjørnland; S. Pettersen; S.S. Garman-Vik; E. Emilsen; J.M. Nesland; Ø. Fodstad; O. Engebraaten

Book ID
111538697
Publisher
Springer
Year
2003
Tongue
English
Weight
303 KB
Volume
20
Category
Article
ISSN
0262-0898

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In order to define the role of cyclin D1 in the progression of malignant glioma, cells over-expressing cyclin D1 were constructed (a-1 cells). They exhibited significantly increased invasiveness as compared with mock-transfected cells. Since cellular invasion is thought to depend on extracellular-ma