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Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine

✍ Scribed by Rémy Schlichter; Volodymyr Rybalchenko; Pierrick Poisbeau; Marc Verleye; Jean-Marie Gillardin


Book ID
118539811
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
369 KB
Volume
39
Category
Article
ISSN
0028-3908

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Enantioselective modulation of GABAergic
✍ Charles F. Zorumski; Steven J. Mennerick; Douglas F. Covey 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 172 KB 👁 1 views

The effects of enantiomers of the neurosteroid analogues, 3␣-hydroxy-5␣pregnan-20-one (DHP) and 3␣-hydroxy-5␣-androstane-17␤-carbonitrile (ACN), and the benz[e]indene, BI-1, on synaptic currents were examined in microcultures of rat hippocampal neurons. Over the range of 0.1-10 µM, the (ϩ)-enantiome