Low-dose morphine induces hyperalgesia t
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Saeed Esmaeili-Mahani; Noriaki Shimokawa; Mohammad Javan; Nader Maghsoudi; Feres
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Article
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2008
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John Wiley and Sons
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English
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## Abstract Opioids can induce analgesia and also hyperalgesia in humans and in animals. It has been shown that systemic administration of morphine induced a hyperalgesic response at an extremely low dose. However, the exact mechanism(s) underlying opioidโinduced hyperalgesia has not yet been clari