Enhanced cerebral uptake of receptor lig
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P. Doze; A. Van Waarde; P.H. Elsinga; N.H. Hendrikse;; W. Vaalburg
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Article
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2000
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John Wiley and Sons
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English
⚖ 170 KB
👁 2 views
Low cerebral uptake of some therapeutic drugs can be enhanced by modulation of P-glycoprotein (P-gp), an ATP-driven drug efflux pump at the blood-brain barrier (BBB). We investigated the possibility of increasing cerebral uptake of the beta-adrenergic ligands S-1'-[(18)F]-fluorocarazolol (FCAR) and