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Modulation of extracellular signal-regulated kinase (ERK) activity by acute and chronic opioid treatment in neuronal and glial cell lines

✍ Scribed by Lionel Moulédous; Miguel F. Diaz; Howard B. Gutstein

Book ID: 111178397
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 146 KB
Volume: 90
Category: Article
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.2004.02610.x

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## Abstract Glial cell line‐derived neurotrophic factor (GDNF) has been shown to be neuroprotective in animal models of the dopamine deficiency in Parkinson's disease. To examine the role of the extracellular signal‐regulated kinases 1 and 2 (ERK1/2) in this process, we infused a single dose of GDN