Selective inhibition of E-selectin, ICAM
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Karl M. Stuhlmeier; Vilmos Csizmadia; Qi Cheng; Hans Winkler; Fritz H. Bach
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Article
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1994
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John Wiley and Sons
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English
⚖ 544 KB
Endothelial cells, as they normally exist in the vasculature as quiescent cells, perform several functions. In an inflammatory response, endothelial cells are activated to up-regulate a number of genes, including E-selectin (ELAM-l), VCAM-1, ICAM-1, interleukin (IL)-l, IL-8 and plasminogen activator