Tea polyphenols are known to inhibit a wide variety of enzymatic activities associated with cell proliferation and tumor progression. The molecular mechanisms of antiproliferation are remained to be elucidated. In this study, we investigated the effects of the major tea polyphenol (-)-epigallocatech
Modulation of EGF Receptor Activity by Changes in the GM3 Content in a Human Epidermoid Carcinoma Cell Line, A431
โ Scribed by Emmanuelle J. Meuillet; Barbara Mania-Farnell; David George; Jin-Ichi Inokuchi; Eric G. Bremer
- Book ID
- 115603326
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 370 KB
- Volume
- 256
- Category
- Article
- ISSN
- 0014-4827
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Human A431 carcinoma cell line is known to have 30 fold amplified epidermal growth factor receptor (EGF-R) gene. We have studied the effect of steroid hormone dexamethasone (DEX) and protein synthesis inhibitor cycloheximide (CHX) on the expression of EGF-R gene in this cell line. DEX treatment and
Previous studies have documented the activation of Na+/H+ exchange in A431 cells by the addition of epidermal growth factor or serum (Rothenberg et al., 1983b). Here we show that exposure of A4 31 cells to medium of increased osmolarity also leads to activation of Na+/H+ exchange and to an increase