Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance
β Scribed by Lage, H.
- Book ID
- 119980992
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 123 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0007-0920
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## Abstract Twenty previously synthesized fused heterocyclic DNAβtopoisomerase II (Topo II)βinhibiting compounds were investigated for their potential efficacy in various human cancer cell lines that were derived from different tumor entities. Moreover, different multidrugβresistant variants of the