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Modulation of DNA adduct levels in human mononuclear white blood cells and granulocytes by CYP1A1, CYP2D6 and GSTM1 genetic polymorphisms

✍ Scribed by Dorota Butkiewicz; Ewa Grzybowska; Kari Hemminki; Steinar Øvrebø; Aage Haugen; Grażyna Motykiewicz; Mieczysław Chora̧ży


Book ID
117767626
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
205 KB
Volume
415
Category
Article
ISSN
1383-5718

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Polymorphisms of the GSTP1 and GSTM1 gen
✍ Dorota Butkiewicz; Ewa Grzybowska; David H. Phillips; Kari Hemminki; Mieczysław 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 77 KB 👁 2 views

Glutathione S-transferases (GSTs) are an important part of the protection system against a wide range of potentially harmful chemical compounds. GSTP1 and GSTM1 are mainly involved in detoxification reactions of PAH carcinogenic intermediates produced by cytochrome P450 (CYP). Polymorphism of the GS