Modulation of cytotoxic and genotoxic effects of 2-acetylaminofluorene in rat and hamster hepatocytes by 3-methylcholanthrene pretreatment
✍ Scribed by J.A. Holme; E.J. Søderlund; T. Christensen; B. Trygg; C. Bjørnstad
- Book ID
- 113193212
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 89 KB
- Volume
- 181
- Category
- Article
- ISSN
- 0027-5107
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Monolayers of rat hepatocytes metabolize 0.25 mM 2acetylaminofluorene (AA F) to various ether-extractable, watersoluble as well as covalently bound products. The major ether-extractable metabolite formed is 2-aminofluorene (AF), followed by 7-OH-AAF and 9-OH-AAF. Pretreatment of rats with the induce