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Modulation of Class Pi glutathione transferase activity by sulfhydryl group modification

โœ Scribed by Hongxie Shen; Katsuto Tamai; Kimihiko Satoh; Ichiro Hatayama; Shigeki Tsuchida; Kiyomi Sato

Book ID
115708679
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
856 KB
Volume
286
Category
Article
ISSN
0003-9861

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๐Ÿ“œ SIMILAR VOLUMES

Ab initio calculations on hidden modulat
Ab initio calculations on hidden modulators of theta class glutathione transferase activity
โœ J.U. Flanagan; W. King; M.W. Parker; P.G. Board; G. Chelvanayagam ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 152 KB

The glutathione transferases decrease the pKa of glutathione, allowing its deprotonation and the formation of the more reactive thiolate anion. The thiolate is maintained in the active site through a weak conventional hydrogen bond first sphere interaction donated by a Tyr hydroxyl in the Alpha, Mu,