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Modulation of Ca2+-dependent anion secretion by protein kinase C in normal and cystic fibrosis pancreatic duct cells

✍ Scribed by H.S. Cheng; W.S. Wong; K.T. Chan; X.F. Wang; Z.D. Wang; H.C. Chan

Book ID: 117049150
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 278 KB
Volume: 1418
Category: Article
ISSN: 0005-2736
DOI: 10.1016/s0005-2736(99)00011-5

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The effects of protein kinase C (PKC) activation and inhibition on the inositol 1,4,5-trisphosphate (IP 3 ) and cytosolic Ca 2ϩ ([Ca 2ϩ ] i ) responses of rat submandibular acinar cells were investigated. IP 3 formation in response to acetylcholine (ACh) was not affected by the PKC activator phorbol