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Modulation of Ca2+-activated K+ channels in human vascular cells by insulin and basic fibroblast growth factor

โœ Scribed by Johannes Wiecha; Katja Reineker; Michael Reitmayer; Rainer Voisard; Andreas Hannekum; Torsten Mattfeldt; Johannes Waltenberger; Vinzenz Hombach


Book ID
117735066
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
628 KB
Volume
8
Category
Article
ISSN
1096-6374

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The effect of pinacidil, an opener of ATP-sensitive K + (K ATP ) channels, on large-conductance Ca 2+ -activated K+ (BK Ca ) channels was investigated in cultured endothelial cells of human umbilical veins. In whole cell configuration, pinacidil (30 ยตM) increased the amplitude of K + outward current