Modulation of a Glial Blood-Brain Barrier
β Scribed by ARTHUR M. BUTT
- Book ID
- 119865430
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 940 KB
- Volume
- 633
- Category
- Article
- ISSN
- 0890-6564
No coin nor oath required. For personal study only.
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## Abstract The bloodβbrain barrier (BBB) is a specialized structure of the central nervous system (CNS) that restricts immune cell migration and soluble molecule diffusion from the systemic compartment into the CNS. Astrocytes and microglia are resident cells of the CNS that contribute to the form
Numerous infections of the central nervous system are characterized by altered blood-brain barrier (BBB) functions leading to brain damage. To study the mechanisms that cause BBB disruption in these pathologies, we used an in vitro BBB model consisting of a coculture of brain capillary endothelial c