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Modulation by Mianserin Pretreatment of the Chronic Electroconvulsive Shock Effects on the Adrenergic System in the Cerebral Cortex of the Rat

✍ Scribed by IRENA NALEPA; ELŻBIETA CHALECKA-FRANASZEK; JERZY VETULANI

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
946 KB
Volume
11
Category
Article
ISSN
0885-6222

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✦ Synopsis

The effect of a series of electroconvulsive shock (ECS) applied after chronic administration of mianserin was tested in the rat. ECS in the group pretreated with mianserin produced a significantly larger increase in the density of 0,-adrenoceptors, while its effect on P-adrenoceptor density and cyclic AMP response to noradrenaline were independent of the mianserin pretreatment. However, the cyclic AMP response to isoproterenol in the presence of 12-0-tetradecanoylphorbol 13-acetate (TPA) in slices from rats receiving ECS after mianserin pretreatment was significantly higher than in the slices of rats receiving either treatment alone. While ECS did not change the responsiveness of al-adrenoceptors as measured by IP response to noradrenaline, it significantly attenuated the responses when given after mianserin; mianserin alone significantly increased the responsiveness of al-adrenoceptors. All treatments reduced the attenuation of IP response by protein kinase C activator TPA. The results suggest that pretreatment with mianserin may affect the ECS action of direct and PKC-modulated adrenergic response systems.

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