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Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors

✍ Scribed by Pierre-Yves Dakas; Sofia Barluenga; Frank Totzke; Ute Zirrgiebel; Nicolas Winssinger


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
258 KB
Volume
119
Category
Article
ISSN
0044-8249

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## Abstract Abnormally high constitutive activity of protein kinase CK2, levels of which are elevated in a variety of tumours, is suspected to underlie its pathogenic potential. The most widely employed CK2 inhibitor is 4,5,6,7‐tetrabromobenzotriazole (TBB), which exhibits a comparable efficacy tow