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Modular Construction of Fluorescent Lipophosphoramidates by Click Chemistry

✍ Scribed by Mathieu Berchel; Jean-Pierre Haelters; Hélène Couthon-Gourvès; Laure Deschamps; Patrick Midoux; Pierre Lehn; Paul-Alain Jaffrès

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
274 KB
Volume
2011
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

The synthesis of fluorescent lipophosphoramidates is reported. Their modular construction allows several variations of the molecular structure including the separation of the fluorescent probe from the lipophosphoramidate moiety by a short methylene or by a tetraethylene glycol spacer. The last step of the convergent synthesis is a Huisgen click reaction, which assembles the fluorescent probe with the lipophosphoramidate part. Five fluorescent probes have been considered in this study including coumarin, NBD, fluorescein, naphthalimide and cyanine.

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