Modular Response Analysis of Cellular Re
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FRANK J. BRUGGEMAN; HANS V. WESTERHOFF; JAN B. HOEK; BORIS N. KHOLODENKO
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Article
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2002
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Elsevier Science
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English
⚖ 246 KB
The sheer complexity of intracellular regulatory networks, which involve signal transducing, metabolic, and genetic circuits, hampers our ability to carry out a quantitative analysis of their functions. Here, we describe an approach that greatly simplifies this type of analysis by capitalizing on th