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Modifying the host range properties of retroviral vectors

✍ Scribed by Stephen J. Russell; François-Loïc Cosset

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
190 KB
Volume
1
Category
Article
ISSN
1099-498X

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✦ Synopsis

Gene therapy protocols would be greatly facilitated by the availability of targetable injectable vectors which could deliver genes in vivo to speci®c target cells or to speci®c disease sites. Efforts to develop such retroviral vectors are therefore a high priority in gene therapy research. In this review, we describe the current state of our understanding of the structure and function of the retroviral envelope glycoprotein complex. We then discuss the results of the various strategies that have been devised to modify the host range of the retroviral envelope glycoproteins with a view to achieving retroviral vectors capable of delivering their genes in a highly speci®c manner to selected human target cells. The strengths and limitations of these strategies are examined.

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