Modified, pulse field gradient-enhanced inverse-detected HOESY pulse sequence for reduction of t1 spectral artifacts

✍ Scribed by Todd M. Alam; Dawn M. Pedrotty; Timothy J. Boyle

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 237 KB
• Volume: 40
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.1019

✦ Synopsis

Abstract

A modified pulse field gradient (PFG)‐enhanced inverse (^1^H)‐detected 2D heteronuclear Overhauser effect spectroscopy (HOESY) pulse sequence is demonstrated for the acquisition of ^1^H–^7^Li heteronuclear correlations. In practice, t~1~ noise artifacts were observed using the original PFG‐enhanced inverse‐detected HOESY pulse sequence, which degraded the ability to detect accurately weak heteronuclear Overhauser signals. Experimentally it is shown that a simple modification of the PFG‐enhanced inverse‐detected HOESY pulse sequence greatly reduces the t~1~ noise that may result from variations in magnetic susceptibility, and allows improved detection of weak ^1^H–^7^Li correlations. Copyright © 2002 John Wiley & Sons, Ltd.