Modified peptides in anti-cancer vaccines: are we eventually improving anti-tumour immunity?

105Ad7 cancer vaccine stimulates anti-tu

105Ad7 cancer vaccine stimulates anti-tumour helper and cytotoxic T-cell responses in colorectal cancer patients but repeated immunisations are required to maintain these responses

✍ Lindy G. Durrant; Declan J. Buckley; R. Adrian Robins; Ian Spendlove 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 99 KB

105AD7 is a human anti-idiotypic antibody that recognises the binding site of the anti-tumour antibody 791T/36 and can thereby mimic the CD55 antigen. The molecular basis of 105AD7 mimicry has been identified with 3 CDR regions of 105AD7 showing similarity to 3 regions of CD55. These regions have be