Modified Low Density Lipoproteins Decrease the Activity and Expression of Lysosomal Acid Lipase in Human Endothelial and Smooth Muscle Cells

Mutations affecting the binding, interna

Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells

✍ Brown, Michael S. ;Anderson, Richard G. W. ;Goldstein, Joseph L. 📂 Article 📅 1977 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 724 KB

## Abstract Studies comparing the metabolism of low density lipoprotein (LDL) in normal cells and in cells cultured from patients with homozygous familial hypercholesterolemia have disclosed the existence of a receptor for plasma LDL. This receptor has been identified on the surface of human fibrob