Modified GC-phases for the enantiomeric separation of optically active compounds: Crosslinking experiments with polymeric chiral compounds
✍ Scribed by Schomburg, G. ;Benecke, I. ;Severin, G.
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 324 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0935-6304
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✦ Synopsis
Crosslinking experiments for immobilization of the well-known chiral stationary phases XE 6O-~-valine-(S)-and XE 60-~-valine-(R)-a -phenylethylamide within capillary columns have been successfully carried out. Crosslinking was also obtained with mixtures of the chiral compound acrylyl-L-valine-(S)-a-phenylethylamide and the polyethylene glycol Carbowax 20M. Immobilization of 75% to 90% was achieved by crosslinking the polymeric chiral phases, but sometimes up to 100% of these phases remained within the columns after the usual subsequent solvent treatment. The crosslinking of Carbowax 20M with acrylyl-L-valine-(S)-a-phenylethylamide led to a chiral polymer of a polarity different from that of the common siloxane type chiral phases.