Modified and improved method for synthesis of p-halogenated-N-isopropylamphetamine leading to synthesis of “no carrier added” I-131 iodoamphetamine

✍ Scribed by A. Najafi

• Book ID: 102375706
• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: French
• Weight: 353 KB
• Volume: 24
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580241004

✦ Synopsis

1-123 labeled N-isopropyl-p-iodoamphetamine (IMP) has been shown to be an important and useful radiopharmaceutical for measurement of cerebral blood flow (B). Since substituted amphetamines have a strong pharmacological activity, the synthesis of "NO Carrier" Added" (NCA) labeled I M P would be desirable (2). In this paper we would like to report a modified and improved method for the synthesis of para-halogenated-N-isopropylamphetamine and the preparation of NCA 1-131 IMP. using 1-131 sodium iodide and para-bromo-N-isopropyl amphetamine (BrMP) followed by HPLC separation of 1-131 I M P and BrMP using reverse phase chromatography.