✦ LIBER ✦

Modified adipokinetic peptides containing two tryptophan residues and their activities in vitro and in vivo inLocusta

✍ Scribed by M. J. Lee; G. J. Goldsworthy

Book ID: 104691347
Publisher: Springer-Verlag
Year: 1996
Tongue: English
Weight: 666 KB
Volume: 166
Category: Article
ISSN: 0174-1578
DOI: 10.1007/bf00264640

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✦ Synopsis

Locusta migratoria has three adipokinetic hormones, adipokinetic hormone-I, II and III. Adipokinetic hormone-III ( or = 5.33 x 10(-10)mol x 1(-1)) at inhibiting acetate uptake into locust fat body in vitro, especially so when it is only moderately potent in mobilizing lipid in vivo. The Trp7 in adipokinetic hormones-III, alongside the Trp8 characteristic of adipokinetic hormones, is not seen in any other adipokinetic hormones. To test whether this is hormone-III in the assay in vitro, novel peptides were synthesised to include or remove this structural motif. Thus

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