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Modifications on the carboxylic function of kynurenic acid

✍ Scribed by Ferenc Fülöp; István Szatmári; József Toldi; László Vécsei


Book ID
106207998
Publisher
Springer
Year
2011
Tongue
English
Weight
458 KB
Volume
119
Category
Article
ISSN
1435-1463

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The anticonvulsant properties of the endogenous excitatory amino acid antagonist, kynurenic acid (KYA), were studied in prepubescent and adult rats using the amygdaloid kindling model of epilepsy. Treatment with intracerebroventricular KYA (360 nmoles (adult dose) or 240 nmoles (prepuhescent dose))