Modifications of the cerebrospinal fluid IgG concentrations in patients with multiple sclerosis treated with intrathecal steroids
β Scribed by A. R. Massaro
- Publisher
- Springer
- Year
- 1978
- Tongue
- English
- Weight
- 370 KB
- Volume
- 219
- Category
- Article
- ISSN
- 0340-5354
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β¦ Synopsis
Forty-one patients with multiple sclerosis (MS), in the acute exacerbation phase of the disease, were treated with three or four intrathecal injections of triamcinolone retard, 40 mg. Cerebrospinal fluid (CSF) specimens were collected at the first and at the last lumbar puncture, and analyzed for IgG and Albumin. There was a decrease of CSF IgG concentration in the specimens of 85% of the cases which were collected at the last lumbar puncture, compared to the initial concentration. Similarly, the CSF IgG/albumin ratio in the last specimens collected were reduced in 78% of the cases. Both these results are statistically significant.
π SIMILAR VOLUMES
## Abstract The role of viruses in the pathogenesis of multiple sclerosis (MS) is a subject of heated debate. The presence of six different neurotropic viruses was sought, including JC virus (JCV), varicella zoster virus (VZV), human herpesvirus 6 (HHVβ6), and EpsteinβBarr virus (EBV), in cerebrosp