Memory T cell responses are frequently highly restricted in terms of receptor usage. How and when such clonotypic dominance is established remains poorly understood. Here we have investigated the evolution of the T cell responses to an epitope from Epstein-Barr virus (EBV), (FLRGRAYGL), by analyzing
✦ LIBER ✦
Modifications of CD8+ T Cell Function during In Vivo Memory or Tolerance Induction
✍ Scribed by Corinne Tanchot; Séverine Guillaume; Jérôme Delon; Christine Bourgeois; Anke Franzke; Adélaïda Sarukhan; Alain Trautmann; Benedita Rocha
- Book ID
- 117722906
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 218 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1074-7613
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## Abstract 4‐1BBL^–/–^ mice have a defect in recall CD8^+^ T cell responses to viruses, whereas CD4^+^ T cell responses to virus are unimpaired in these mice. In contrast, both CD4^+^ and CD8^+^ T cells respond to 4‐1BB ligand (4‐1BBL) __in vitro__. To clarify the role of 4‐1BB/4‐1BBL in CD4^+^ ve