Changes in phospholipase D isoform activ
Changes in phospholipase D isoform activity and expression in multidrug-resistant human cancer cells
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Giusy Fiucci; Malgorzata Czarny; Yaakov Lavie; Di Zhao; Brygida Berse; J. Krzysz
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Article
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2000
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John Wiley and Sons
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French
β 171 KB
Multidrug resistance (MDR) is a major cause of failure of cancer chemotherapy and is often associated with elevated expression of drug transporters such as P-glycoprotein (P-gp) in the cancer cells. MDR is, however, accompanied by additional biochemical changes including modifications of membrane co