✦ LIBER ✦

Modification of titanium alloy surfaces for percutaneous implants by covalently attaching laminin

✍ Scribed by David J. Gordon; Dimpu D. Bhagawati; Catherine J. Pendegrass; Claire A. Middleton; Gordon W. Blunn

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 759 KB
Volume: 9999A
Category: Article
ISSN: 1549-3296
DOI: 10.1002/jbm.a.32735

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Percutaneous implants require a seal at the skin interface. Laminin (L‐332) is a component of the basement membrane, integral to epidermal attachment. To enhance the attachment of keratinocytes onto the surface of titanium alloy (Ti~6~Al~4~V), we attached L‐332 onto the surface using silanization (L‐332Ti~6~Al~4~V). Iodinated L‐332 was used to investigate protein attachment kinetics. L‐332Ti~6~Al~4~V remained attached after immersion in serum compared with adsorbed L‐332. Cells from a keratinocyte line (HaCaT) grown on L‐332Ti~6~Al~4~V were significantly smaller (p < 0.05) with over a 20‐fold increase in the number of adhesion plaques compared with nontreated Ti~6~Al~4~V control discs or with adsorbed L‐332 surfaces. We have shown that it is possible to augment the surface of Ti~6~Al~4~V with L‐332 and that this significantly increases the attachment of keratinocytes. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 2010

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